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Chol Lim, Ph.D.

 


Senior Research Fellow

Blanchette Rockefeller Neurosciences Institute


Email: Clim@brni.org 

Phone: 304-293-0527

Fax: 304-293-7536

 

 


Education:

 

  • B.S. (Biochemistry), Kyungpook National University, Daegu, South Korea
  • M.S. (Molecular and Cellular Biology), Gwangju Institute of Science and Technology, (GIST), Gwangju, South Korea
  • Ph.D. (Molecular and Cellular Biology), Gwangju Institute of Science and Technology, (GIST), Gwangju, South Korea
  • Research Investigator (Neuroscience), Hanwha Chemical R&D Center, Daejeon, South Korea
  • Postdoctoral fellow (Neurobiology), University of Connecticut, Storrs, CT, USA  

 

Research Interests:

 

Dr. Lim’s focus of research is the study of protein kinase C (PKC) activation mechanism on dendritogenesis and synaptogenesis and its regulation via neurotrophic factors signaling in the hippocampus.  His goal is to evaluate effective treatments against neurodegenerative disease such as Alzheimer’s disease (AD) and mental retardation disease such as autistic spectrum disorders (ASDs), that will be PKC activators.  

 

Synaptic loss is an early hallmark of neurodegenerative diseases such as AD and this loss is highly linked to the loss of learning ability and memory function in AD patients.  In addition, in ASDs, mental retardation diseases, the mutations of several important synaptic proteins result in change of dendritic spine morphology, loss of functional synapses, and memory deficits, and highly linked to the disease severity of ASDs. 

 

As many other results have been shown that PKC activation plays pivotal role in neuroprotection and synaptogenesis, PKC activators can be effective treatment to prevent or cure against AD or ASDs. 
 

Areas of Expertise: 

 

Neurology, Neuroscience and Biochemistry

 

 

Awards:

 

1) February 2004 - Best Research Award (GIST, Gwangju, South Korea)

2) August 2003 - Young Scientist Award (Korean Society for Cell Biology, South Korea)

 

 

Recent Patents and Publications:

 

1) Patents – Novel use of lignan compounds [International application #: PCT/KR2006/001212 (03.31.2006)/International publication #: WO 2006/104369 A1 (10.05.2006)] and 2 Korean patents

 

2) Publications

 

1.    Chol Seung Lim, Yoo Kyeong Hwang, Donghak Kim, Seung Hyun Cho, Cristina Banuelos, Jennifer L. Bison, and Jung-Soo Han (2011) Increased interactions between PKA and NF-kB signaling in the hippocampus following loss of cholinergic input. Neuroscience. (Accepted)
 

2.    Chol Seung Lim, Youn Jung Kim, Yoo Kyeong Hwang, Christina Banuelos, Jennifer L. Bizon, and Jung-Soo Han (2011) Decreased interactions in PKA-GR signaling in the hippocampus after selective removal of the basal forebrain cholinergic input. Hippocampus. (In Press)
 

3.    Chol Seung Lim and Randall S. Walikonis (2008) Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway. Cellular Signaling. 20(5): 825-835

4.    Chol Seung Lim, Da-Qing Jin, Jin-Young Sung, Ji Hee Lee, Han Gil Choi, Ilho Ha and Jung-Soo Han. (2006) Antioxidant and anti-inflammatory activities of the methanolic extract of Neorhodomela aculeate in hippocampal and microglial cells. Biological and Pharmaceutical Bulletin. 29(6): 1212-1216
 

5.    Da-Qing Jin, Chol Seung Lim, Jin-Young Sung, Han Gil Choi, Ilho Ha and Jung-Soo Han. (2006) Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells. Neuroscience Letter. 402(1-2): 154-158
 

6.    Dae Joong Kim, Sung Hyun Kim, Chol Seung Lim, Kyu Yeong Choi, Chun Shik Park, Bong Hwan Sung, Myeong Gu Yeo, Sunghoe Chang, Jin-Kyu Kim and Woo Keun Song. (2006) Interaction of  SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation. Journal of Biological Chemistry. 281(1): 617-625
 

7.    Chol Seung Lim, Da-Qing Jin, Hyejung Mok, Sang Jin Oh, Jung Uk Lee, Jae Kwan Hwang, Ilho Ha and Jung-Soo Han (2005) Antioxidant and antiinflammatory activities of Xanthorrhizol in hippocampal neurons and primary cultured microglia. Journal of Neuroscience Research. 82(6): 831-838
 

8.    Da-Qing Jin, Chol Seung Lim, Jae Kwan Hwang, IlHo Ha and Jung-Soo Han (2005) Anti-oxidant and anti-inflammatory activities of Macelignan in murine hippocampal cell line and primary culture of rat microglial cells. Biochemical and Biophysical Research Communications. 331(4): 1264-1269
 

9.    Chol Seung Lim, Sung Hyun Kim, Jin Gyoung Jung, Jin-Kyu Kim and Woo Keun Song (2003) Regulation of SPIN90 Phosphorylation and Interaction with Nck by ERK and Cell Adhesion. Journal of Biological Chemistry. 278(52): 52116-52123

10.    Dae Joong Kim, Sang Hee Park, Chol Seung Lim, Jang-Soo Chun, Jin-Kyu Kim and Woo Keun Song (2003) Cellular Localization of Integrin Isoforms in Phenylephrine-induced Hypertrophic Cardiac Myocytes. Cell Biochemistry and Function. 21(1): 41-48
 

11.    Chol Seung Lim, Eui Sun Park, Dae Joong Kim, Young Hwa Song, Soo Hyun Eom, Jang-Soo Chun, Jae Hong Kim, Jin-Kyu Kim, Dongeun Park and Woo Keun Song (2001) SPIN90 (SH3 Protein Interacting with Nck, 90 kDa), an Adaptor Protein That Is Developmentally Regulated during Cardiac Myocyte Differentiation. Journal of Biological Chemistry. 276(16): 12871-12878
 

12.    Young Youn Kim, Chol Seung Lim, Young Hwa Song, Joohong Ahnn, Dongeun Park and Woo Keun Song (1999) Cellular Localization of a3b1 Integrin Isoforms in Association with Myofibrillogenesis during Cardiac Myocyte Development in Culture. Cell Adhesion and Communication. 7(2): 85-97
 

13.    Min Seong Kwon, Chol Seung Lim, and Woo Keun Song (1997) Effect of Lysophosphatidic Acid on Proliferation and Differentiation of Rat Skeletal Myoblasts in Culture. Korean J. Biol. Sci. 1(4): 641-646

       
       
       

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