Publications

Alkon DL, Acosta-Urquidi J, Olds J, Kuzma G, Neary J: Protein kinase injection reduces voltage-dependent potassium currents. Science 219: 303-306, 1983.

Alkon DL, Lederhendler I, Shoukimas JJ: Primary changes of membrane currents during retention of associative learning. Science 215: 693-695, 1982.

Alkon DL, Nelson T, Zhao W, Cavallaro S: Time domains of neuronal calcium signaling and associative memory: steps through a calexcitin, ryanodine receptor, K+ channel cascade. Trends in Neuroscience 21:529-537, 1998.

Alkon DL, Rasmussen H: A spatial-temporal model of cell activation. Science 239: 998-1005, 1988.

Alkon DL: Calcium-mediated reduction of ionic currents: A biophysical memory trace. Science 226: 1037-1045, 1984.

Alkon DL: Learning in a marine snail. Scientific American 249: 70-84, 1983.

Alkon DL: Membrane depolarization accumulates during acquisition of an associative behavioral change. Science 210: 1375-1376, 1980.

Alkon DL: Memory storage and neural systems. Scientific American 260: 42-50, 1989.

Ascoli GA, Luu KX, Olds JL, Nelson TJ, Gusev PA, Bertucci C, Bramanti E, Raffaelli A, Salvadori P, Alkon DL: Secondary structure and Ca2+-induced conformational change of Calexcitin, a learning-associated protein. J Biol Chem 272: 24771-24779, 1997.

Cavallaro S, D'Agata V, Manickam P, Dufour F, Alkon D: Memory-specific temporal profiles of gene expression in the hippocampus. Proc Natl Acad Sci USA, 99:16279-16284, 2002.

Collin C, Papageorge AG, Lowy DR, Alkon DL: Early enhancement of calcium currents by H-ras oncoproteins injected into Hermissenda neurons. Science 250: 1743-5, 1990.

Farley J, Alkon DL: Neural organization predicts stimulus specificity for a retained associative behavioral change. Science 210: 1373-1375, 1980.

Farley J, Richards WG, Ling LJ, Liman E, Alkon DL: Membrane changes in a single photoreceptor cause associative learning in Hermissenda. Science 221: 1201-1203, 1983.

Lederhendler I, Gart S, Alkon DL: Classical conditioning in Hermissenda: Origin of a new response. J Neurosci. 6:(5): 1325-1331, 1986.

LoTurco JL, Coulter DA, Alkon DL: Enhancement of synaptic potentials in rabbit CA1 pyramidal neurons following classical conditioning. Proc Natl Acad Sci USA 85(5): 1672-1676, 1988.

Meiri N, Ghelardini C, Tesco G, Galeotti N, Dahl D, Tomsic D, Cavallaro S, Quattrone Capaccioli S, Bartolini A, Alkon DL: Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat. Proc Natl Acad Sci USA 94:4430-4434, 1997.

Meiri N, Sun MK, Segal Z, Alkon DL: Memory and long-term potentiation (LTP) dissociated: normal spatial memory despite CA1 LTPL elimination with Kv1.4 antisense. Proc Natl Acad Sci USA 95:15037-15042, 1998.

Neary JT, Alkon DL: Protein phosphorylation/dephosphorylation and the transient, voltage-dependent potassium conductance in Hermissenda crassicornis. J Biol Chem. 258: 8979 -8983, 1983.

Neary JT, Crow T, Alkon DL: Change in a specific phosphoprotein band following associative learning in Hermissenda. Nature 293: 658-660, 1981.

Nelson T, Collin C, Alkon DL: Isolation of a G protein that is modified by learning and reduces potassium currents in Hermissenda. Science 247: 1479-1483, 1990.

Olds JL, Anderson M, McPhie DL, Staten L, Alkon DL: Imaging memory-specific changes in the distribution of protein kinase c within the hippocampus. Science 245: 866-869, 1989.

Olds JL, Golski S, McPhie DL, Olton D, Mishkin M, Alkon DL: Discrimination learning alters the distribution of protein kinase C in the hippocampus of rats. J Neurosci 10: 3707-13, 1990.

Pascale A, Gusev P, Amadio M, Dottorini T, Govoni S, Alkon DL, Quattrone A: Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Proc Natl Acad Sci USA 101: 1217-1222, 2004.

Quattrone A, Pascale A, Nogues Z, Zhao W, Gusev P, Pacini A, Alkon DL: Posttranscriptional regulation of gene expression in learning by the neuronal ELAV like mRNA-stabilizing proteins. Proc Natl Acad Sci USA 98: 11668-73, 200l.

Schreurs BG, Gusev PA, Tomsic D, Alkon DL, Shi, T: Intracellular correlates of acquisition and long-term memory of classical conditioning in Purkinje cell dendrites in slices of rabbit cerebellar lobule HVI. J Neuroscience18: 5498-5507, 1998.

Schreurs BG, Tomsic D, Gusev, PA, Alkon DL: Dendritic excitability microzones and occluded long-term depression after classical conditioning of the rabbit's nictating membrane response. J Neurophysiol. 77: 86-92, 1997.

Sun MK, Alkon DL: Carbonic anhydrase gating of attention: memory therapy and enhancement. Trends in Pharmacol Sci. 23: 2, 83-89, 2002.

Sun MK, Alkon DL: Carbonic anhydrase gating of attention: memory therapy and enhancement. Trends in Pharmacol Sci. 23: 2, 83-89, 2002.

Zhao W, Alkon DL: Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol. 177: 125-34, 200l.

Zhao W, Cavallaro S, Gusev P, Alkon DL: Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions. Proc Natl Acad Sci USA 97: 8098-8103, 2000.

Zhao W, Chen H, Xu H, Moore E, Meiri N, Quon MJ, Alkon DL: Brain insulin receptors and spatial memory: Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem. 274: 34893-34902, 1999.

Zhao WQ, Chen GH, Chen H, Pascale A, Ravindranath L, Quon MJ, Alkon DL: Secretion of annexin II via activation of insulin receptor and insulin-like growth factor receptor. J Biol Chem. 278:4205-15, 2003.

Alkon DL, Epstein H, Kuzirian A, Bennett, MC, Nelson T. Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning. Proc Natl Acad Sci USA 102(45): 16432-16437, 2005.

Sun MK, Alkon DL. Dual effects of bryostatin-1 on spatial memory and depression. Eur J Pharmacol. 512: 45-51, 2005.

Etcheberrigaray R, Tan M, Dewachter I, Kuiperi C, Van der Auwera I, Wera S, Qiao L, Bank B, Nelson TJ, Kozikowski AP, Van Leuven F, Alkon DL: Therapeutic effects of PKC activators in Alzheimer’s disease transgenic mice. Proc Natl Acad Sci USA 101(30): 11141-11146, 2004.

Sun MK, Nelson TJ, Xu H, Alkon DL: Calexcitin transformation of GABAergic synapses: from excitation filter to amplifier. Proc Natl Acad Sci USA 96:7023-7028, 1999.

Sun MK, Alkon DL: Carbonic anhydrase gating of attention: memory therapy and enhancement. Trends in Pharmacol Sci. 23: 2, 83-89, 2002.

Zhao WQ, Ravindranath L, Mohamed AS, Zohar O, Chen CH, Lyketsos CG, Etcheberrigaray R, Alkon DL: MAP kinase signaling cascade dysfunction specific to Alzheimer's disease in fibroblasts. NeuroBiol Disease, 11: 166-183, 2002.

Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL: Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer's disease. Proc Natl Acad Sci USA 90: 8209-13, 1993.

Etcheberrigaray R, Ito E, Kim S, Alkon DL: Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. Science 264: 276-9, 1994.

Favit A, Grimaldi M, Nelson TJ, Alkon DL: Alzheimer's-specific effects of soluble β-amyloid on protein kinase C-β and -β degradation in human fibroblasts. Proc Natl Acad Sci USA 10:5562-5567, 1998.

Khan TK, Alkon DL. An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin. Proc Natl Acad Sci USA 103 (35): 13203-13207, 2006.

Nelson TJ, Backlund P, Yergey AL, Alkon D: Hippocampal protein-protein interactions in spatial memory. Hippocampus 14(1): 46-57, 2004

Nelson T, Backlund PS Jr, Yergey AL, Alkon DL: Isolation of protein subpopulations undergoing protein-protein interactions. Mol Cell Proteomics, 1, 3: 253-9, 2002.

Sun MK, Nelson T, Alkon DL: Functional switching of GABAergic synapses by ryanodine receptor activation. Proc Natl Acad Sci USA 97: 22, 12300-12305, 2000.

Sun MK, Dahl D, Alkon DL: Heterosynaptic transformation of GABAergic gating in the hippocampus and effects of carbonic Anhydrase inhibition. J Pharm Exper Therap. 296:3, 811-817, 200l.

Sun MK, Alkon DL: Carbonic anhydrase gating of attention: memory therapy and enhancement. Trends in Pharmacol Sci. 23: 2, 83-89, 2002.