Patents/Publications
 Daniel L. Alkon, MD, left, and Robert M. D’Alessandri, MD, display patents awarded from the U.S. Patent Office to BRNI scientists in 2004. |
BRNI is an independent, not-for-profit research institute working in the area of memory and, in particular, Alzheimer's disease. The Institute is aggressive in capturing its discoveries and intellectual property. Applications for patents are filed to provide protection on an international basis, typically including the United States of America, Europe, and Asia.
The Institute seeks collaboration with the private sector and offers these technologies for partnership and licensing as a means of moving our discoveries into commercialization of products that benefit the public and to fund further discovery work.
Please address inquires regarding licensing and technology transfer to brni-webmaster@brni.org or to mcochran@brni.org.
Examples of intellectual property currently available for licensing include:
- Alzheimer's disease diagnostics based on specific alteration of internally controlled Erk1/Erk2 phosphorylation ratio
- Methods to enhance cognitive ability
- Methods to treat cognitive decline
- Methods for neuroprotection
- Methods to enhance learning
- Methods for delivery of drugs across the Blood-Brain-Barrier
- Methods for treatment of hypoxia-induced learning and memory
impairment - Methods of treating depression
Recently published studies include:
Conditioning-specific reflex modification of rabbit (Oryctolagus cuniculus) heart rate by Bernard G. Schreurs et al., Behavioral Neuroscience; 2005, vol. 119(6), pp.1484-1495.
Topography of Arc/Arg3.1 mRNA expression in the dorsal and ventral hippocampus induced by recent and remote spatial memory recall: dissociation of CA3 and CA1 activation by Pavel A. Gusev et al., The Journal of Neuroscience; 2005, vol. 25(41), pp. 9384-9397.
Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration by Thomas J. Nelson et al., Biochemical Society Transactions; 2005, vol. 33(5), pp. 1033-1036.
Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning by Daniel L. Alkon et al., Proceedings of the National Academy of Sciences USA; 2005, vol. 102(45), pp. 16432-16437.
Morphine protects for head trauma induced cognitive deficits in mice by Ofer Zohar et al., Neuroscience Letters; 2006, vol. 394(3), pp. 239-242.
Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice by Dong Ping Tan et al., Proceedings of the National Academy of Sciences USA; 2006, vol. 103(13), pp. 5125-5130.